There are three primary access points into Point Loma: Rosecrans Street from Old Town to the northeast, Harbor Drive past the airport from the east, and Nimitz Boulevard from Mission Bay to the north.

The Metropolitan Transportation System operates buses in San Diego. Route 28 on Rosecrans Street and Route 35 to Ocean Beach connect to the trolley station in Old Town, while Route 923 goes on Harbor Drive past the airport to Downtown.
A less conventional way of getting into the area is by taking a Water Taxi, +1 619 235-8294.

These small boats serve San Diego Bay and offer service to Harbor Island and Shelter Island from Coronado and Downtown. They run from 3PM-10PM daily and cost $7 each way, and can be a good way to get to the yachts, hotels, and restaurants of Harbor and Shelter Islands, but if you’re planning on heading virtually anywhere else in the Point Loma-Ocean Beach area, a Water Taxi isn’t going to be much help.